Title: Safety and Tolerability of Nevirapine-based Antiretroviral Therapy in HIV-infected Patients Receiving Fluconazole for Cryptococcal Prophylaxis: a case-control study Short running head title: Safety of Nevirapine used with Fluconazole Key words: HIV, nevirapine, antiretroviral therapy, fluconazole, adverse events Authors:
نویسندگان
چکیده
2 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand Email: Weerawat Manosuthi * [email protected]; Nopphanath Chumpathat [email protected]; Achara Chaovavanich [email protected]; Somnuek Sungkanuparph [email protected] * Corresponding author Corresponding author: Weerawat Manosuthi, M.D. Department of Medicine, Bamrasnaradura Institute, Tiwanon Road, Nonthaburi, 11000, Thailand. Tel. 66-2-5903408 Fax. 66-2-5903411 Email. [email protected]
منابع مشابه
Safety and tolerability of nevirapine-based antiretroviral therapy in HIV-infected patients receiving fluconazole for cryptococcal prophylaxis: a retrospective cohort study
BACKGROUND To compare the adverse events after initiation of NVP-based ART among HIV-infected patients who did not receive fluconazole (group A), received fluconazole 400 mg/week (group B), and received fluconazole 200 mg/day (group C). METHODS A retrospective cohort study was conducted among HIV-infected patients who began NVP-based ART between December 2003 and September 2004. Patients were...
متن کاملIntegrated therapy for HIV and cryptococcosis
Cryptococcosis has been one of the most common opportunistic infections and causes of mortality among HIV-infected patients, especially in resource-limited countries. Cryptococcal meningitis is the most common form of cryptococcosis. Laboratory diagnosis of cryptococcosis includes direct microscopic examination, isolation of Cryptococcus from a clinical specimen, and detection of cryptococcal a...
متن کاملPlasma nevirapine levels, adverse events and efficacy of antiretroviral therapy among HIV-infected patients concurrently receiving nevirapine-based antiretroviral therapy and fluconazole
BACKGROUND The clinical data of plasma NVP level, safety and efficacy of antiretroviral therapy (ART) for the concurrent use of nevirapine (NVP)-based ART and fluconazole (FLU) is scanty. METHODS A retrospective study was conducted in patients who were initiated NVP-based ART between October 2004 and November 2005. The objectives were to compare NVP levels, adverse events, and 36-week efficac...
متن کاملCo-administration of fluconazole increases nevirapine concentrations in HIV-infected Ugandans
BACKGROUND Data from retrospective studies have suggested that there may be an interaction between fluconazole and nevirapine, increasing nevirapine concentrations and potentially leading to hepatotoxicity. METHODS This study was nested within a large double-blind placebo-controlled study designed to determine if primary prophylaxis with fluconazole (200 mg three times per week) could reduce ...
متن کاملPrimary prophylaxis of cryptococcal disease with fluconazole in HIV-positive Ugandan adults: a double-blind, randomised, placebo-controlled trial.
BACKGROUND Cryptococcal disease remains an important cause of morbidity and mortality in HIV-infected individuals in sub-Saharan Africa, despite the introduction of antiretroviral therapy. We studied fluconazole as primary prophylaxis against cryptococcal disease in patients awaiting or starting antiretroviral therapy in Uganda. METHODS In this prospective, double-blind randomised controlled ...
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تاریخ انتشار 2005